No Media Kings has a great article discussing the ins and outs of various self-publishing methods. The article includes a great little how to on how do bind your own hardcover books that is definitely worth checking out. Offset printing, Print on Demand Services, and DIY Perfect binding are also covered making this a great article for aspiring authors or for people who want to do small one time printing and/or binding.
Related: Also check out the Book Binding Flickr Pool, where you can find tons of pictures from peoples self binding projects.

Related: Here is a start to finish photo journal of stitch binding a comic book pointed out by MAKE.

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